Faculty
Department of Anesthesiology
Martin Kaczocha, Role of fatty acid binding proteins in pain, inflammation, and related pathophysiologies: Endocannabinoid pharmacology and development of novel therapeutics.
Department of Biochemistry and Cell Biology
Michael Airola, Structural biology of lipid modifying enzymes
Ivet Bahar,Molecular systems biology, modeling and simulations of structural dynamics and interactions, design of modulators of function, applications to complex diseases
Nurit Ballas, The cellular and molecular mechanisms underlying the neurodevelopmental disorder Rett syndrome
Paul M. Bingham, Genetic control of development and gene expression in animals
Vitaly Citovsky, Nuclear targeting and intercellular communication in plants
Neta Dean, Glycosylation; fungal pathogenesis
Ken Dill, Computer modeling of protein molecules and theory and principles of the machine mechanisms and evolution of cells
J. Peter Gergen, Gene expression and development in Drosophila
Steven Glynn, Structure and mechanism of protein-unfolding machines in mitochondria
Kathryn Gunn, Spatiotemporal regulation of metabolic enzymes
Bernadette C. Holdener, Genetic regulation of early mammalian development
Chi-Kuo Hu , Assistant Professor, biology of dormancy during development and aging, with the African killifish as the main research organism.
Wali Karzai, Biochemical, Structural, and Mechanistic Explorations of Protein and RNA Homeostasis.
Erwin London, Membrane protein structure/translocation/folding
Benjamin Lin, Cell dynamics and motility
Ed Luk, Chromosome biology and genome regulation
Benjamin Martin, Stem cell maintenance and differentiation, Developmental mechanisms of cancer pathogenesis
Aaron Neiman, Vesicle trafficking and membrane/cytoskeletal interactions
Jonathan Nelson, Repetitive DNA and transposable element regulation and its impact on maintaining genome stability
Dada Pisconti, Muscle stem cells; muscle development, regeneration and aging; muscular dystrophy; extracellular matrix; biology of proteoglycans.
Stuti Sharma, Mechanisms of membrane transporters using cryo-electron microscopy and biochemical tools
Gerald H. Thomsen, Growth factors /signal transduction in early vertebrate development
Department of Chemistry
Elizabeth Boon, Nitric oxide regulation of quorum sensing and biofilm formation in bacteria
Scott Laughlin, Chemical and biological strategies for deciphering neural circuitry
Carlos Simmerling, Development of tools for efficient and simulation of chemical systems and using them to study the structure and dynamics of molecules involved in biological processes.
Peter Tonge, Spectroscopic insights into enzyme mechanisms and structure
Department of Medicine
Agnieszka Bialkowska, Acute and chronic pancreatitis, pancreatic cancer development, animal models, pancreatic stromal and immune cell interactions, single-cell and bulk NGS
Wen-Tien Chen, Proteases / integrins in cancer invasion, metastasis, angiogenesis
Christopher Clarke, Oncogenic reprogramming of sphingolipid metabolism and role in tumorigenesis
Berhane Ghebrehiwet, Biochemistry; function of the complement system
Yusuf Hannun, Bioactive lipids in cancer pathogenesis and therapeutics
Weiqin Lu, The major goal of my research is to unravel the role of inflammation and obesity in promoting oncogenic KRAS-mediated pancreatic tumorigenesis
Cungui Mao, Bioactive sphingolipids in cell growth, differentiation, apoptosis, and autophagy
Vincent Yang, Biology and pathobiology of intestinal epithelial stem cells and colorectal cancer.
Huichun Zhan, Stem cell biology in normal and neoplastic hematopoiesi
Department of Molecular Genetics & Microbiology
Jorge Benach, Pathogenesis of spirochetal infections and their host responses
Nicolas Carpino, Positive and Negative Regulation of T cell Receptor Signaling
Bruce Futcher, Cell cycle, cyclins, and yeast genetics
Patrick Hearing, Adenovirus regulation of cellular proliferation and gene expression; adenovirus vectors for human gene therapy
Hwan Kim, Rickettsial pathogenesis and vaccine assembly for tick-borne rickettsioses
James Konopka, Signal transduction, morphogenesis and genetics of pathogenic fungi
Pawan Kumar, Immunology, gut microbiota-immune cells interaction. Intestinal and autoimmune inflammation
Erich R. Mackow, Viral Pathogenesis, Regulation of Innate Immunity, Hantavirus, Dengue Virus and Rotavirus Regulation of Cell Signaling Responses, miRNAs and Endothelial cell functions.
Nancy Reich, Cytokine and Innate Immune Responses
Brian Sheridan, Mucosal Immunology, T cell memory, Vaccine design, Host-pathogen interactions
David Thanassi, Secretion of virulence factors by bacterial pathogens; pilus biogenesis by uropathogenic Escherichia coli
Adrianus. W.M. van der Velden, Infectious Diseases Immunology; Host Interactions with Bacterial Pathogens; Bacterial Immune Subversion
Department of Neurobiology and Behavior
Maurice Kernan, Molecular basis of mechanical senses
David McKinnon, Molecular physiology of sympathetic neurons and cardiac muscle
Markus Riessland, We use state-of-the-art molecular tools to study cell type-specific pathways that underlie selective vulnerability and cellular senescence in brain-aging, age-related neurodegeneration and Parkinson’s disease.
Roger Sher, Genetic, molecular, and cellular mechanisms in Neurodegeneration
Prerana Shrestha, Developing tools to manipulate protein synthesis, Translation control of long-term memories, and Stress-induced emotional dysregulation in anxiety disorders
Howard Sirotkin, Genetic and molecular analysis of early vertebrate development
Lonnie Wollmuth, Molecular mechanisms of synaptic transmission
Department of Oral Biology and Pathology
Soosan Ghazizadeh, Epithelial stem cell biology; Skin bioengineering and gene therapy.
Department of Pathology
Jiang Chen, Skin and hair follicle development, maintenance and malignancy
Fei Chen, Metabolic and epigenetic reprogramming of chemical carcinogenesis.
Jun Chung, Anti-cancer drug discovery targeting tumor invasion and metastasis
Mehdi Damaghi, The role of tumor microenvironment in evolution of metabolic phenotypes in breast and ovarian cancer: from single cells to whole tumor analysis
Jingfang Ju, Post-transcriptional control of non-coding RNAs and RNA binding proteins in cancer
Richard R. Kew, Leukocyte chemotaxis/inflammation
Yupo Ma, Stem cell reprogramming and therapy, genome engineering, blood and marrow transplantation
Luis Martinez, Oncogenes and tumor suppressor genes, oncogenic functions of mutant p53
Ute Moll, Tumor suppressor genes; mechanism of p53 inactivation
Scott Powers, Genomic approaches to cancer research
Kenneth Shroyer, Cancer biomarkers as diagnostic adjuncts in cervical pathology and cytopathology; cervical cancer and HPV
Zhishan Wang, Environmental carcinogenesis, Cancer biology and Cancer therapy.
Chengfeng Yang, RNA dysfunction in carcinogenesis and resistance to cancer therapies
Wei Yang, Harnessing the power of multi-level proteomics to understand and prevent cancer metastasis
Department of Pharmacological Sciences
Christopher Brownlee, Leveraging microfluidics and optogenetics to elucidate molecular mechanisms of spindle orientation, ciliogenesis, polarity, actin cortex formation and axonogenesis
Holly Colognato, Extracellular matrix in the brain; roles during development and during neurodegeneration.
Bruce Demple, Defining new repair pathways for oxidative DNA damage in the nucleus and the mitochondria of mammalian cells.
Michael A. Frohman, Lipid signaling pathways in immune responses, Alzheimer's disease, cardiovascular disease, and cancer.
Miguel Garcia-Diaz, Genetic Toxicology/Mechanisms of mitochondrial gene expression
Arthur Grollman, Mechanisms of chemical mutagenesis/carcinogenesis
Hyungjin Kim, Mechanisms of DNA damage response and repair in cancer susceptibility pathways
Joav Prives, Cytoskeletal membrane interactions in muscle cells
Gilbert Rahme, Cancer epigenetics with a focus on brain tumors
Jessica C. Seeliger, Molecular mechanisms of bacterial cell membrane assembly
Markus Seeliger, Mechanism of Protein kinases and Ubiquitin Ligases in Cancer and Aging
Ken-Ichi Takemaru, Wnt Signaling in Development and Disease
Dongyan Tan, Structure and function of macromolecules involved in epigenetic regulation of gene expression
Styliani-Anna Tsirka, Neuronal-microglial interactions in the central nervous system
Ledong Wan, Role of RNA splicing in inflammation and cancer
Department of Physiology and Biophysics
Richard Lin, Kinase signaling and cell proliferation
W. Todd Miller, Tyrosine phosphorylation and signal transduction
Eugene Serebryany, Protein folding, misfolding, aggregation, and conformation-phenotype relationships; disulfide bonds and protein chemistry; single-molecule protein sequencing; protein and peptide libraries
Ilan Spector, Neuronal differentiation and microfilaments
Thomas White, Molecular biology and physiology of gap junction channels
Brookhaven National Laboratory
Qun Liu, Structural biology of membrane proteins and host-pathogen interactions, cellular structural biology.
F. William Studier, Phage T7 replication; large-scale nucleotide sequencing
Cold Spring Harbor Laboratory
Christopher Hammell, Understanding how temporal precision in gene regulation contributes to normal development and how the modulation of protein translation impacts human cancer biology
Leemor Joshua-Tor, Structural biology; nucleic acid regulation; RNAi; molecular recognition; X-ray crystallography
Adrian Krainer, mRNA splicing; gene expression; RNA-protein interaction
Robert Martienssen, Plant genetics; transposons; development; gene regulation; DNA methylation
Alea Mills, Cancer; development; aging; senescence; epigenetics
David L. Spector, Spatial organization of gene expression
Bruce Stillman, DNA replication and chromatin assembly in human and yeast cells
Nicholas K. Tonks, Characterization of protein tyrosine phosphatases
Lloyd Trotman, TheRapidCaP system to study metastatic prostate cancer genomes and their resistance to therapy in vivo
David A. Tuveson, Our laboratory investigates the fundamental mechanisms that contribute to the pathogenesis of pancreatic cancer, and applies this information to the development of new therapeutic and diagnostic approaches
Christopher Vakoc, Chromatin; epigenetics; acute myeloid leukemia; self-renewal; RNAi screening; mouse models of cancer
Linda Van Aelst, Signal transduction; Ras and Rac proteins, tumorigenesis
Michael H. Wigler, Growth control in yeast and mammalian cells